Author: modernpony14

Cannabinoids

What Do We Know About Cannabinoids Other Than CBD and THC?

April 14th, 1912, 11:40 p.m. The Titanic, a state-of-the-art cruise liner, collided with an iceberg, creating one of history’s most memorable events. After that, the rest is history. Surprisingly, the berg scratched the hull below the waterline on the starboard, or right, side. In fact, about 90% of an iceberg is below the waterline on average. It’s difficult to identify what’s hidden underwater just by looking at the area you can see. There’s a lot more to this storey than meets the eye.

So, how does all of this historical rambling relate to us?

CBD, along with THC, is one of the most abundant cannabinoids found in cannabis sativa plants, as detailed in earlier blog postings. CBD and tetrahydrocannabinol (THC) are only the tip of the iceberg when it comes to cannabis (the iceberg being the hemp plant). These are the most common cannabinoids, hence they’re also the most studied.

However, beneath the surface of the water, there is a whole universe of cannabinoids and naturally occurring chemical chemicals that science has yet to discover. In fact, the hemp plant (a member of the cannabis sativa family) has over 480 distinct chemicals, with over 140 of them classified as cannabinoids.

Taking a Deeper Look Underneath the Surface

Let’s take a deep breath and dive beneath the surface of the water to investigate what additional key cannabinoids exist in the hemp plant besides CBD and THC.

Let’s begin at the very beginning. When a hemp seed is planted, it contains just trace amounts of THC (if any at all). As a result, hemp seeds and hemp seed oil are widely available in stores. When the seed sprouts, however, magic begins to happen, and cannabigerol (CBG) is produced. It’s the mother or father of all cannabinoids, in a sense.

Let’s talk about CBG, as well as a few other intriguing cannabinoids that have the potential to change people’s lives.

Cannabigerol is a cannabinoid found in cannabis (CBG)

As previously stated, CBG serves as the parent molecule from which all other cannabinoids are produced. The majority of CBG is transformed into other cannabinoids throughout plant growth, leaving only about 1% of CBG in mature plants.

CBG, like CBD, but unlike THC, does not produce a “high” effect. You know how 50 is the new 40 and orange is the new black? CBG has been dubbed the “new CBD” by some. In fact, a lot of study is being done on CBG’s potential benefits. However, because CBG is in such short supply, its price reflects this.

As a comparison, a kilo of gold costs roughly $55K, while a kilo of CBG can cost as much as $50K. Isn’t it a little shabby?

Even the US government is interested in this cannabis. The National Center for Complementary and Integrative Health (NCCIH) stated in 2018 that 9 studies on cannabinoids and pain have been funded.

CBG interacts with the two principal chemical receptors in the endocannabinoid system (ECS), CB1 and CB2, in the same way as other cannabinoids do. CB1 receptors are mostly found in the brain and neurological system, whereas CB2 receptors are found in the immune system.

The ECS is in charge of pain, hunger, hormones, inflammation, and blood pressure regulation, among other things.

Cannabichromene is a kind of cannabichromene that is (CBC)

 

CBC, like CBG and CBD, may have similar effects but is scarce in the hemp plant, making it highly expensive to produce and use.

You will not get high on CBC because it is non-intoxicating. While CBC does not bind well to the CB1 receptor in the ECS, it has been discovered to bind to other receptors in the body, which has piqued researchers’ curiosity. They believe that CBC has immense promise, but that further research is needed before any judgments can be drawn.

CBC, like other cannabinoids, appears to have a synergistic impact with other cannabinoids, resulting in the entourage effect.

 

Cannabinol is a kind of cannabis (CBN)

CBN is a bit of an anomaly. CBN is an exception to the rule that most cannabinoids are generated actively from CBG throughout the hemp plant’s maturation process.

CBN is produced when THC is oxidised and is typically present in older cannabis (exposed to oxygen over time).

To put it another way, CBN was once THC.

Because CBN is produced when THC ages, it is common

 

ly found in high concentrations in older cannabis.

CBN binds to both CB1 and CB2 receptors, similar to CBD and THC, but has a stronger binding with the CB2 receptor. CBN also works as an agonist for the TRPV2 re

 

ceptor, a naturally occurring protein that controls a number of biological systems in the human body.

Cannabidiol (CBD) is a cannabicyclol (CBL)

 

CBL is one of the least researched cannabinoids, with minimal research on its possible advantages. CBL has only been found as a component of the cannabis plant and its biosynthesis by scientists, who have yet to investigate how it affects humans. CBL isn’t thought to have psychedelic properties, and it’s unclear whether it binds to ECS receptors.

CBL was detected in an ancient cannabis sam

 

ple unearthed in a Chinese tomb and dated to around 2700 BCE. CBN and CBL were the two most abundant cannabinoids in this sample, respectively. THC was undetectable, while CBD levels were substantially lower (although the presence of CBN and other metabolites indicate it was once high in THC).

Cannabinoids and Their World

These are only a few of the several cannabinoids found in hemp plants. Cannabinodiol (CBDL), cannabielsoin (CBE), and cannabitriol are some of the others (CBT). While further research is needed to establish the potential advantages of these cannabinoids to the human body, the fact that there are still so many more to discover is fascinating.

 

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Cannabigerol

What is CBG, and how does it compare to CBD?

Cannabigerol is abbreviated as CBG. CBG is an important phytocannabinoid in part because it serves as a precursor to numerous other phytocannabinoids, including as CBD, CBN, and CBC, which all develop naturally in the developing hemp plant. CBG functions as a building block for other beneficial plant chemicals in this way. Some CBG does, however, stay as CBG, but the amount is usually relatively tiny. Since its discovery in 1964, CBG has been classified as a minor cannabinoid due to its modest levels of occurrence. That is, until now!

As scientists learn more about the complicated chemistry of the hemp plant, research reveals that CBG may have certain specific properties that could be very advantageous. CBG, like CBD, is non-intoxicating, which means it won’t make you feel “high.”

What Is CBG and What Does It Do?
As previously stated, CBG aids in the production of CBD and CBC in the developing hemp plant. Despite the fact that they are all phytocannabinoids, they have distinct chemical structures and appear to have both similar and dissimilar effects. By interacting in diverse ways with our endocannabinoid system, most phytocannabinoids enhance the creation of our own endocannabinoids (ECS). The ECS’s major receptor sites are known as CB1 and CB2. CB1 receptors are primarily found in the central nervous system and spinal cord, while CB2 receptors are primarily found in our organs and immune system.

CBG appears to interact with CB1 receptors in a way that balances the effects of other cannabinoids, according to research. It also appears to bind strongly with CB2 receptor sites(1), implying that CBG may play an important function in physiological system regulation. Furthermore, CBG may be unusual among phytocannabinoids in its ability to interact with a variety of receptor locations throughout the body, not just those found in the ECS. (2)

More research is needed to understand how CBG functions and what, if any, ramifications it has for our bodies. There haven’t been any human studies of CBG yet, but in vitro (cell studies in a test tube) and animal studies point to some interesting potential.

What Are CBG’s Main Potential Benefits?
Hundreds of scientific investigations have identified a variety of potential health benefits, but what is the major potential benefit of CBG?

Anxiety and Stress in Everyday Life

It should come as no surprise that CBG helps to reduce anxiety and tension in everyday life. According to the results of an animal study, CBG may aid with anxiety, stress, and muscle tension by altering the effects of GABA, a brain neurotransmitter. (3) This could be another instance of CBG interacting with body systems other than the ECS. Another animal behaviour study found evidence that CBG may have the ability to improve mood. (4)

What is the best way to take CBG?
Higher quantities of CBG in hemp extracts are now more attainable because to advances in research and production techniques. Hemp extracts with a high CBG content, as well as CBG-dominant hemp extracts, will likely become more widely available as oils, ingestibles, and topicals. The advantage of utilising CBG oil is that you can gradually raise (or reduce) the amount of CBG you take each day, depending on how your body reacts. You might find topical medicines useful if research continues to build on the ostensibly promising findings of CBG.

What will CBG make me feel like, and how long will it take for it to work?
“It depends,” is the quick answer to both inquiries, just as it is for CBD. It relies on a number of elements, including the starting position of your body’s systems and the CBG concentration you’re employing. The final fact is that CBG can have a variety of effects on various people, and it works gradually over time. Dietary supplements like Charlotte’s WebTM are designed to work in harmony with your body. Results occur in the form of gradual progress, which will make positive improvements more sustainable as time goes on.

To Sum Everything Up
Because most CBG spontaneously changes into other phytocannabinoids when still in the young hemp plant, research on CBG has traditionally been more challenging. As a result, only little amounts of genuine CBG were available for research. However, in recent years, this scenario has begun to shift. More research is needed, particularly human clinical trials, as all previous CBG research has used isolated cells or laboratory animals.

Despite this, CBG’s discoveries appear to be very promising, and scientific knowledge of how this unusual phytocannabinoid functions will continue to expand. More research is needed to better understand how lesser-known cannabinoids, such as CBG, affect the human body.

Even while CBG appears to have distinct effects and interacts with receptor sites other than those identified in the ECS, it’s likely that all cannabinoids operate together in complimentary and overlapping ways to create a healthy body response. As a result, we propose full-spectrum hemp extracts, which contain all of the beneficial components found in hemp plants and will work together to boost your body’s good response.…

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Marijuana

What Is the Entourage Effect, and How Does It Affect CBD?

You may have come across the term “Entourage Effect” while investigating the benefits of cannabidiol, or CBD, and full-spectrum hemp extracts. But what exactly does that imply, and why is it significant?

Israeli scientists invented the phrase “Entourage Effect” to describe how hemp’s cannabinoids, minerals, and chemicals interact within the human body. Scientists discovered that while a single cannabinoid from hemp can be beneficial, these phytocompounds work together to support overall health even more. While CBD receives a lot of attention, an extract containing other valuable phytocompounds can assist CBD in doing its purpose.

Charlotte’s Web CBD oils and capsules are more than just CBD because of this. We don’t want to miss out on any health benefits. Every serving of our full-spectrum hemp extract contains over 100 phytocannabinoids, terpenes, and flavonoids derived from the complete plant.

If you’re unfamiliar with the words, phytocannabinoids and cannabinoids are cannabinoids generated by hemp and other plants (as opposed to endocannabinoids that are produced within the human body). Cannabidiol (CBD), Cannabigerol (CBG), Cannabichromene (CBC), and other cannabinoids are among them. Terpenes are a type of oil found in hemp and other plants that has a pleasant scent. They bind to receptors in the human body and provide a wide range of health advantages. Finally, flavonoids are a class of phytonutrients that act as cell messengers while also providing health advantages.…

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